Snecko Eye is great if you have several 2 or more cards. Obviously the boss relics make a huge difference as well. On mid ascensions I relied on either a lot of defense (Shrug It Offs, Ghostly Armor) and then sort of waited for the run to decide to go all in on defense (Barricade, Entrench) or go more offense with strength scaling (Spot Weakness, Inflame, Demon Form). Its hard to write a guide since each run is different but here is some general things I noticed. ![]() As you get to higher ascension different cards become more valuable.
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